Problem with an insisting virus?

My PC is infected to a virus which I cant enter any drive except windows drive,and If you want to enter an other drive the windows will be closed,I tested all ways,such as going theought Run and some Anti virus software such az Mac Afee and Esset but I couldent success and I changed windows over and over but it wasnt useful,what should I do?
I am going to suicide because of this virus