Safe to remove the drive. Floppy drives are now disfunctional, and most if not all new PC's do not come with a floppy drive anymore.
PC Doc
July 2012
You can remove it without any risk at all.
The A: and B: drives leters can't be used for any hard drive, but are great to mount network drives.
It will only free up a port, normaly an USB one, if it's an external drive. An internal one connector ONLY work for a floppy drive, but removing the now useless ribon cable will improve the air flow in the case.
Electro
July 2012
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