I don't know but if it always happens on one particular application then either there's a very weird software incompatibility or (I include this because it's happend to my son's machine) if you have a high specification graphics card it may be overheating - could be it's been wound up too fast or that the cooling fan is starting to fail - you can inspect the fan with a mirror with the side panel removed.
The RAM and the Hard Disk are very unlikely to be the cause of your problem provided that you have enough space available to meet the minimum requirements of the application - check the small print.
Good luck...
Peccavi
May 2010