If you try to sign on a clerk and it doesn't work then you need to do an 'initial clear'. This will not clear your programming so don't worry. But if nothing else works there is a chance the battery on your mother board has died and the first time the electricity is cut to the machine you loose the program in the register. Also a bad keyboard will cause the same problem. The ER-5100 series had bad keyboards. They used little metal 'tits' that after lots of use would cut into the printed circuit contact below a much used key. The later, much improved keyboards are great.
Robert
May 2015